Growing evidence suggests that psychedelic drugs can help people explore aspects of their identity that were previously hidden, including sexual orientation and gender. Therapists and researchers say these substances may loosen deeply held assumptions about the self, creating space for reflection and change.

Hunt Priest, a former Episcopal clergyman in the US, identified as straight for most of his life before taking part in a psilocybin trial at Johns Hopkins University in 2016. While the experience did not immediately change his sexuality, he later noticed increased openness and emotional awareness, which he believes allowed him to act on feelings he had never fully acknowledged. He is now in a long-term relationship with a man.

Researchers caution that it is difficult to isolate the effects of psychedelics from other life changes. Still, a growing body of studies suggests these drugs can increase psychological openness and help people re-examine identity-related beliefs shaped by social norms.

A survey published in March 2025 involving 581 psychedelic users found that some participants experienced changes in attraction or greater flexibility in how they understood their sexuality. Around 10% also reported shifts in gender identity or expression, with some describing experiences that felt “beyond gender” altogether.

Experts emphasise that psychedelics do not create identities but may help people access feelings and questions that already existed. Clinical psychologists note that these substances can temporarily quiet rigid self-concepts, making it easier to explore sensitive topics without shame or fear.

While interest in psychedelic-assisted therapy is growing as laws slowly change, specialists warn that these substances carry risks and should not be used casually. Supportive environments and professional guidance are considered essential, particularly when experiences lead to major personal or relational changes.

For some, these experiences offer clarity and self-acceptance. For others, they raise complex questions that take time to process. Researchers agree on one point: when used carefully, psychedelics can open a powerful window into how people understand who they are.